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Puppets without Pants, the comic stylings of Jette Petersen!
Abstruse Goose, a random and lovely comic.
We the Robots, a comic about robots.
Left-Handed Toons, by right-handed people.
xkcd, A webcomic of romance, sarcasm, math, and language.
Math Bunnies, maintained by frequent commenter Wing.
A Geek Story (sketches), a delightful diversion for geeks or geek-watchers.